BioGRID ORCS Build 1.0.3 added 325 new CRISPR-Cas9 screens for cancer therapeutic targets from Behan FM et al. (2019)

BioGRID ORCS build 1.0.3 (our latest update) added nearly 400 new screens to our CRISPR database including 325 from our latest featured dataset, "Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens." by Behan FM et al. (Nature, 2019). This comprehensive dataset is comprised of genome-scale CRISPR-Cas9 screens in 324 human cancer cell lines from 30 cancer types, and is developed to prioritize candidates for cancer therapeutics.

A special thanks to the authors Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, and Garnett MJ and the Garnett Group, Yusa Group, Saez Lab, Heidelberg University, Open Targets, and the Wellcome Sanger Institute.

If you have a CRISPR Screen Dataset you'd like to deposit directly into the BioGRID ORCS CRISPR Database, please contact us at

October 11th, 2019 - 02:38 PM