Migration of Post-Translational Modifications to Improved Viewer from Interaction Format

BioGRID has made improvements to the post-translational modification (PTM) viewer in order to introduce new features, in particular to display PTMs that have not been mapped to a specific site in the protein. With these improvements, we have also completed an extensive project to migrate 57,819 PTMs from interaction records and into the PTM viewer for the BioGRID 3.4.125 release. Notably, for the covalent protein modifier ubiquitin, 49,425 covalent PTMs were previously housed as protein interaction records in BioGRID and demarcated in the associated notes as "likely ubiquitin conjugate". The segregation of covalent protein modification records from non-covalent protein interaction records allows a precise distinction between the two types of interaction, and reduces the dominance of ubiquitin as a super-hub in protein interaction networks. Non-covalent interactions between ubiquitin and components of the ubiquitin-proteasome system are still retained as interaction records. All post-translational modifications for any given query protein can now be viewed on the associated PTM summary page (Examples: TP53, RELA, DIG1, SUMO1). For a complete list of protein interaction records affected by these changes, please see the BioGRID download page [Interactions Migrated to PTM Viewer (excel file)].

If you have questions, comments or suggestions regarding this release please feel free to contact us at any time.

The BioGRID Team

June 1st, 2015 - 04:45 AM