CRISPR Screen Dataset
Kuehnle N (2023) - 1-PMID36801923
Title: CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death.
Screen Details:
- Screen Rationale : Cell essential genes in a CFLAR KO mutant
- Cell Type : Primary Effusion Lymphoma Cell Line [BTO:0002719]
- Cell Line : BCBL-1 [CELLOSAURUS:CVCL_0165, BTO:0002727]
- Phenotype : Cell Proliferation
- Condition : Mutation: CFLAR (ETG8837) KO
- Library : Brunello (human) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 24 | Full Dataset Size: 19,084
- Experimental Setup : Timecourse | Duration: 24 Days | MOI: = 0.3
- Significance : Authors used a complex method to determine significant results. Please refer to the source publication for more details. Significant results are indicated by '' in the HIT column of the table below.
Notes:
- Hit genes are those that resulted in increased growth when CFLAR encoding cFLIP was also KO by sgRNA
Score Distribution
< 1
> 0.00000000341