CRISPR Screen Dataset

Name: CRISPR SCREEN: Martin TD (2021) - 8-PMID34529489 (The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.)
Creator: BioGRID Project

Martin TD (2021) - 8-PMID34529489

M. musculus

Title: The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.

Screen Details:

Screen Rationale : Tumor cell survival
Cell Type : Colonic Cancer Cell Line [BTO:0000797]
Cell Line : CT26 [BTO:0003630, CELLOSAURUS:CVCL_7254]
Phenotype : Tumorigenicity
Library : Mouse druggable genome (Elledge, 2021) | Type: CRISPRn | Format: in vivo | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : MaGeCK | Number of Hits: 44 | Full Dataset Size: 7,253
Experimental Setup : Implantation to Mouse Model
Significance : Authors have indicated that results with Score.4 (FDR) < 0.1 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Notes:

Hit genes are significantly depleted upon KO in a tumor sample grown in immunocompetent hosts

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 7253

> 1

CRISPR Screen Results (44 hits)

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