CRISPR Screen Dataset

Name: CRISPR SCREEN: Martin TD (2021) - 6-PMID34529489 (The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.)
Creator: BioGRID Project

Martin TD (2021) - 6-PMID34529489

M. musculus

Title: The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.

Screen Details:

Screen Rationale : Growth inhibition of tumor cells in an immunodeficient host
Cell Type : Breast Adenocarcinoma Cell Line [BTO:0001912]
Cell Line : 4T1 [BTO:0004311, CELLOSAURUS:CVCL_0125]
Phenotype : Tumorigenicity
Condition : SCID BALB/c host
Library : Mouse druggable genome (Elledge, 2021) | Type: CRISPRn | Format: in vivo | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : MaGeCK | Number of Hits: 18 | Full Dataset Size: 7,253
Experimental Setup : Implantation to Mouse Model
Significance : Authors have indicated that results with Score.4 (FDR) < 0.1 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Notes:

Hit genes are significantly enriched upon KO in a tumor sample grown in a SCID BALB/c (immunocompromised) mice

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 7253

> 1

CRISPR Screen Results (18 hits)

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