CRISPR Screen Dataset
Martin TD (2021) - 2-PMID34529489
Title: The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.
Screen Details:
- Screen Rationale : Tumor cell survival
- Cell Type : Breast Adenocarcinoma Cell Line [BTO:0001912]
- Cell Line : 4T1 [BTO:0004311, CELLOSAURUS:CVCL_0125]
- Phenotype : Tumorigenicity
- Library : Mouse druggable genome (Elledge, 2021) | Type: CRISPRn | Format: in vivo | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 198 | Full Dataset Size: 7,253
- Experimental Setup : Implantation to Mouse Model
- Significance : Authors have indicated that results with Score.4 (FDR) < 0.1 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Hit genes are significantly depleted upon KO in a tumor sample grown in immunocompetent wildtype mice
Score Distribution
< 7253
> 1