CRISPR Screen Dataset
Manzano M (2018) - 10-PMID30111820
Title: Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.
Screen Details:
- Screen Rationale : Cell-essential and growth restrictive genes
- Cell Type : Primary Effusion Lymphoma Cell Line [BTO:0002719]
- Cell Line : VG-1 [CELLOSAURUS:CVCL_0106]
- Phenotype : Cell Proliferation
- Library : Brunello (human) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 264 | Full Dataset Size: 18,884
- Experimental Setup : Timecourse | Duration: 14 Days | MOI: = 0.3
- Significance : Authors have indicated that results with Score.2 (FDR) < 0.05 OR Score.4 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Genes with a significant Mageck neg score are cell essential in the VG-1 cell line
- Genes with a significant Mageck pos score are growth restrictive in the VG-1 cell line
Score Distribution
< 0.99999
> 0.00000000352