CRISPR Screen Dataset
Baccelli I (2019) - 1-PMID31287994
Title: Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.
Screen Details:
- Screen Rationale : Increased/decreased drug resistance
- Cell Type : Pre-B Acute Lymphoblastic Leukemia Cell Line [BTO:0000603]
- Cell Line : NALM-6 [BTO:0003288, CELLOSAURUS:CVCL_0092]
- Phenotype : Response To Chemicals
- Condition : Mubritinib (200.0 nM) [PubChem]
- Library : Extended Knockout Library (EKO) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : RANKS | Number of Hits: 3 | Full Dataset Size: 18,998
- Experimental Setup : Drug Exposure | Duration: 7 Days
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Hit genes with a negative RANKS score show synthetic lethality with mubritinib treatment upon KO
- Hit genes with a positive RANKS score show increased resistance to mubritinib treatment
Score Distribution
< 3.63
> -4.09