CRISPR Screen Dataset
Benslimane Y (2021) - 1-PMID33660365
Title: A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.
Screen Details:
- Screen Rationale : Increased/decreased drug resistance
- Cell Type : Pre-B Acute Lymphoblastic Leukemia Cell Line [BTO:0000603]
- Cell Line : NALM-6 [BTO:0003288, CELLOSAURUS:CVCL_0092]
- Phenotype : Response To Chemicals
- Condition : BIBR 1532 (BIBR1532) (20 µM) [PubChem, ChemSpider]
- Library : Extended Knockout Library (EKO) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : RANKS | Number of Hits: 109 | Full Dataset Size: 18,989
- Experimental Setup : Drug Exposure | Duration: 20 Days
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.07 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Hit genes with a negative RANK score show increased sensitivity to BIBR1532 upon KO (synthetic lethal)
- Hit genes with a positive RANK score show increased resistance to BIBR1532 upon KO (synthetic rescue)
Score Distribution
< 5.46
> -4.05