CRISPR Screen Dataset
Krosl J (2022) - 1-PMID34731885
Title: Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia.
Screen Details:
- Screen Rationale : Increased/decreased drug resistance
- Cell Type : Pre-B Acute Lymphoblastic Leukemia Cell Line [BTO:0000603]
- Cell Line : NALM-6 [BTO:0003288, CELLOSAURUS:CVCL_0092]
- Phenotype : Response To Chemicals
- Condition : cerivastatin (150.0 nM) [ChEBI]
- Library : Extended Knockout Library (EKO) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : RANKS | Number of Hits: 216 | Full Dataset Size: 19,025
- Experimental Setup : Drug Exposure | Duration: 8 Days
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Hit genes with a negative RANKS score show increased statin sensitivity
- Hit genes with a positive RANKS score show decreased statin sensitivity
Score Distribution
< 7.19
> -6.28