CRISPR Screen Dataset

Name: CRISPR SCREEN: Navare AT (2022) - 1-PMID36305789 (Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.)
Creator: BioGRID Project

Navare AT (2022) - 1-PMID36305789

H. sapiens

Title: Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.

Screen Details:

Screen Rationale : GBF1 Synthetic Lethal or Suppressor Genes
Cell Type : Pre-B Acute Lymphoblastic Leukemia Cell Line [BTO:0000603]
Cell Line : NALM-6 [BTO:0003288, CELLOSAURUS:CVCL_0092]
Phenotype : Response To Chemicals
Condition : golgicide A (GCA) (4.0 µM) [ChEBI]
Library : Extended Knockout Library (EKO) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : RANKS | Number of Hits: 70 | Full Dataset Size: 19,029
Experimental Setup : Drug Exposure | Duration: 8 Days
Significance : Authors have indicated that results with Score.3 (FDR) < 0.05 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Notes:

Hit genes with a negative RANKS score are synthetically lethal with GBF1 chemical inhibition
Hit genes with a positive RANKS score suppress sensitivity to GBF1 chemical inhibition

View More Screens from this Publication | Download Source Supplementary File

Score Distribution

< 5.19

> -5.57

CRISPR Screen Results (70 hits)

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