CRISPR Screen Dataset
Guo D (2022) - 1-PMID35420441
Title: SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection.
Screen Details:
- Screen Rationale : Increased/decreased sensitivity to virus
- Cell Type : Cervical Adenocarcinoma Cell Line [BTO:0005590]
- Cell Line : HeLa [BTO:0000567, CELLOSAURUS:CVCL_0030]
- Phenotype : Response To Virus
- Condition : Virus: Enterovirus 71 (0.1 nM) [NCBI Taxid 39054]
- Library : GECKO v2 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 2,267 | Full Dataset Size: 21,473
- Experimental Setup : Virus Exposure | Duration: 2 Days | MOI: < 0.3
- Significance : Authors have indicated that results with Score.2 (p-Value) <= 0.05 OR Score.4 (p-Value) <= 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Genes with a significant positive MAGeCK score are genes whose KO results in decreased sensitivity to the virus.
- Genes with significant negative MAGeCK score are genes whose KO results in increased sensitivity to the virus.
Score Distribution
< 1
> 0.0000000000000632