CRISPR Screen Dataset
Sanghvi VR (2021) - 1-PMID33562682
Title: NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Pro-B-lymphocyte [BTO:0003103]
- Cell Line : FL5.12 [BTO:0003328, CELLOSAURUS:CVCL_0262]
- Phenotype : Response To Chemicals
- Condition : silvestrol (10.0 nM) [ChEBI]
- Library : mouse CRISPRn library (Yusa, 2013) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : DESeq | Number of Hits: 17 | Full Dataset Size: 15,829
- Experimental Setup : Drug Exposure
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Authors screened for genes whose KO confers resistance to silvestrol
Score Distribution
< 10.8659206
> -4.158574509