CRISPR Screen Dataset
Norton JP (2021) - 1-PMID34016692
Title: Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas.
Screen Details:
- Screen Rationale : Cell-essential genes
- Cell Type : Small Cell Lung Cancer [BTO:0000189]
- Cell Line : Rb1/Trp53-deleted SCLC mouse
- Phenotype : Cell Proliferation
- Library : GECKO v2 (mouse) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 764 | Full Dataset Size: 20,611
- Experimental Setup : Timecourse | Duration: 12 Doublings | MOI: < 1.0
- Significance : Authors have indicated that ALL results are to be considered significant.
Notes:
- Authors screened for gene necessary for SCLC cell growth
Score Distribution
< 0.003333
> 0.000000000325