CRISPR Screen Dataset
He YJ (2018) - 2-PMID30464262
Title: DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Cancer Cell Line [EFO:0001639]
- Cell Line : COV362 [EFO:0006383, CELLOSAURUS:CVCL_2420]
- Phenotype : Response To Chemicals
- Condition : Cisplatin [ChemSpider]
- Library : GECKO | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : STARS | Number of Hits: 61 | Full Dataset Size: 18,080
- Experimental Setup : Drug Exposure | Duration: 14 Days
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.01 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Score Distribution
< 10.03102812
> 2.361219262