CRISPR Screen Dataset
Ehrenhöfer-Wölfer K (2019) - 10-PMID31406271
Title: SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.
Screen Details:
- Screen Rationale : Cell-essential genes
- Cell Type : Cancer Cell Line [EFO:0001639]
- Cell Line : KYSE-450 [EFO:0006630, CELLOSAURUS:CVCL_1353]
- Phenotype : Cell Proliferation
- Library : CRISPRn targeted epigenetic regulator library (Wöhrle, 2019) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : Robust-rank aggregation (RRA) | Number of Hits: 77 | Full Dataset Size: 179
- Experimental Setup : Timecourse | Duration: 18 Doublings | MOI: ~ 0.3
- Significance : Authors have indicated that results with Score.1 (RRA score) < -0.5 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Score Distribution
< 0
> -9.624