CRISPR Screen Dataset
Fang P (2019) - 1-PMID31508509
Title: Genome-scale CRISPR knockout screen identifies as a modifier of PARP inhibitor sensitivity.
Screen Details:
- Screen Rationale : Increased/decreased drug resistance
- Cell Type : Ovarian Cancer Cell Line [BTO:0000811, EFO:0002394]
- Cell Line : A2780 [EFO:0006362, CELLOSAURUS:CVCL_0134]
- Phenotype : Response To Chemicals
- Condition : Olaparib (5.0 µM) [PubChem]
- Library : GECKO v2 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : Z-score based on MAGECK score | Number of Hits: 20 | Full Dataset Size: 19,937
- Experimental Setup : Drug Exposure | Duration: 7 Days | MOI: ~ 0.3
- Significance : Authors used a complex method to determine significant results. Please refer to the source publication for more details. Significant results are indicated by '' in the HIT column of the table below.
Notes:
- Hit genes cause increased or decreased sensitivity to Olaparib
Score Distribution
< 23.167
> -13.992