CRISPR Screen Dataset
Pluvinage JV (2019) - 1-PMID30944478
Title: CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.
Screen Details:
- Screen Rationale : Regulators of phagocytosis
- Cell Type : Microglial Cell Line [BTO:0003349]
- Cell Line : BV-2 [BTO:0003350, CELLOSAURUS:CVCL_0182]
- Phenotype : Phagocytosis
- Library : Bassik Mouse CRISPR Knockout Library: Drug targets, kinases, phosphatases and Membrane Proteins sub-libraries [AddGene, AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : CasTLE | Number of Hits: 286 | Full Dataset Size: 2,967
- Experimental Setup : Drug Exposure | Duration: 7 Days | MOI: < 1
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Score Distribution
< 161
> 0