CRISPR Screen Dataset
Urbanek K (2020) - 1-PMID33087464
Title: Cytidine monophosphate N-acetylneuraminic acid synthetase and solute carrier family 35 member A1 are required for reovirus binding and infection.
Screen Details:
- Screen Rationale : Increased resistance to virus
- Cell Type : Microglial Cell Line [BTO:0003349]
- Cell Line : BV-2 [BTO:0003350, CELLOSAURUS:CVCL_0182]
- Phenotype : Response To Virus
- Condition : Virus: Reovirus (strain T3SA+) (100.0 MOI) [NCBI Taxid 10891]
- Library : Asagio (mouse) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : STARS | Number of Hits: 895 | Full Dataset Size: 20,077
- Experimental Setup : Virus Exposure | Duration: 9 Days | MOI: = 0.2
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.25 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Hit genes represent host factors required for reovirus-induced cell killing
Score Distribution
< 15.43897608
> 0.53528884