CRISPR Screen Dataset

Zhan T (2020) - 2-PMID33186476

H. sapiens

Title: Multi-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155.

Screen Rationale : Increased/decreased drug resistance
Cell Type : Colorectal Cancer Cell Line [BTO:0001616]
Cell Line : HCT 116 [BTO:0001109, CELLOSAURUS:CVCL_0291]
Phenotype : Response To Chemicals
Condition : navitoclax (750 nM) [ChEBI]
Library : TKO (Toronto Knockout) v1 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : MaGeCK | Number of Hits: 2 | Full Dataset Size: 17,153
Experimental Setup : Drug Exposure | Duration: 12 Days
Significance : Authors have indicated that results with Score.2 (FDR) < 0.2 OR Score.4 (FDR) < 0.2 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.

Authors screened a particular molecular subtype of colorectal cancer for increased resistance (positive score FDR<0.2) or decreased resistance (negative score FDR<0.2) to the BCL2 suppressor navitoclax

< 0.99988

> 0.00000204