CRISPR Screen Dataset
Chai AWY (2020) - 2-PMID32990596
Title: Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.
Screen Details:
- Screen Rationale : Cell-essential genes
- Cell Type : Oral Squamous Cell Carcinoma Cell Line [BTO:0002211]
- Cell Line : ORL-115 [CELLOSAURUS:CVCL_S690]
- Phenotype : Cell Proliferation
- Library : Human Improved Genome-wide Knockout CRISPR Library [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 993 | Full Dataset Size: 17,995
- Experimental Setup : Timecourse | Duration: 18 Days | MOI: = 0.3
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Authors screened for genes whose KO resulted in decreased fitness in this oral squamous carcinoma cell line
Score Distribution
< 1
> 1.78e-16