CRISPR Screen Dataset
Tromp AT (2018) - 1-PMID29736038
Title: Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin.
Screen Details:
- Screen Rationale : Increased resistance to toxin
- Cell Type : Lymphoma Cell Line [BTO:0000104]
- Cell Line : U-937 [BTO:0001412, CELLOSAURUS:CVCL_0007]
- Phenotype : Response To Toxin
- Condition : PVL (Panton–Valentine leukocidin) (31.0 nM)
- Library : CRISPRn (Spaan, 2018) | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 20 | Full Dataset Size: 18,611
- Experimental Setup : Toxin Exposure | Duration: 27 Days
- Significance : Authors used a complex method to determine significant results. Please refer to the source publication for more details. Significant results are indicated by '' in the HIT column of the table below.
Notes:
- KO of the hit gene confers increased resistance to the to the S. aureus leukocidin PVL
Score Distribution
< 1
> 2.75e-50