CRISPR Screen Dataset
Wu X (2020) - 1-PMID32005668
Title: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
Screen Details:
- Screen Rationale : Increased drug resistance
- Cell Type : Acute Myeloid Leukemia Cell Line [BTO:0001883]
- Cell Line : Unknown
- Phenotype : Response To Chemicals
- Condition : DNMDP (25.0 nM) [PubChem]
- Library : Brunello (human) [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : Log2 Fold Change (L2FC) | Number of Hits: 4 | Full Dataset Size: 19,548
- Experimental Setup : Drug Exposure | Duration: 14 Days | MOI: = 0.3
- Significance : Authors have indicated that results with Score.2 (p-Value) > 5.6 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- KO of the gene increases resistance to DNMDP cancer cell killing
Score Distribution
< 8.168846492
> -5.625640729