CRISPR Screen Dataset
Ma H (2015) - 1-PMID26190106
Title: A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death.
Screen Details:
- Screen Rationale : Increased resistance to virus
- Cell Type : Embryonic Kidney Cell Line [BTO:0002733]
- Cell Line : HEK293-FT [BTO:0005029, CELLOSAURUS:CVCL_6911]
- Phenotype : Response To Virus
- Condition : Virus: West Nile virus (2 MOI) [NCBI Taxid 11077]
- Library : Human genome-wide library v1 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : None | Number of Hits: 7 | Full Dataset Size: 20,121
- Experimental Setup : Virus Exposure | Duration: 12 Days
- Significance : Authors used a complex method to determine significant results. Please refer to the source publication for more details. Significant results are indicated by '' in the HIT column of the table below.
Notes:
- KO of these genes increases survival of cell exposed to West Nile virus
- These genes are essential to killing by West Nile virus
Score Distribution
< 35061
> 10