CRISPR Screen Dataset
Li Y (2019) - 1-PMID31019072
Title: Genome-wide CRISPR screen for Zika virus resistance in human neural cells.
Screen Details:
- Screen Rationale : Increased resistance to virus
- Cell Type : IPSC Derived Cell Line [EFO:0005740]
- Cell Line : iPSC derived neural progenitor
- Phenotype : Response To Virus
- Condition : Virus: Zika virus (1.0 MOI) [NCBI Taxid 64320]
- Library : Human Activity-optimized genome-wide library [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : Log2 Fold Change (L2FC) | Number of Hits: 133 | Full Dataset Size: 18,386
- Experimental Setup : Virus Exposure | Duration: 8 Days | MOI: ~ 0.4
- Significance : Authors have indicated that results with Score.1 (Log2FC) > 1.562 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- the authors describe the top scoring genes as "protective gene knockout hits"
Score Distribution
< 6.587789176
> -4.716164185