CRISPR Screen Dataset
Labeau A (2020) - 1-PMID31915280
Title: A Genome-Wide CRISPR-Cas9 Screen Identifies the Dolichol-Phosphate Mannose Synthase Complex as a Host Dependency Factor for Dengue Virus Infection.
Screen Details:
- Screen Rationale : Increased resistance to virus
- Cell Type : Chronic Myelogenous Leukemia Cell Line []
- Cell Line : HAP-1 [EFO:0007598, CELLOSAURUS:CVCL_Y019]
- Phenotype : Response To Virus
- Condition : Virus: Dengue virus 2 Jamaica/1409/1983 (5 MOI) [NCBI Taxid 11064]
- Library : GECKO v2 [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 17 | Full Dataset Size: 20,062
- Experimental Setup : Virus Exposure | Duration: 2 Weeks
- Significance : Authors have indicated that results with Score.3 (FDR) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Notes:
- Phenotypic readout: cell proliferation
Score Distribution
< 0.99999
> 8.78e-16