CRISPR Screen Dataset

Name: CRISPR SCREEN: Tsvetkov P (2019) - 1-PMID31133756 (Mitochondrial metabolism promotes adaptation to proteotoxic stress.)
Creator: BioGRID Project

Tsvetkov P (2019) - 1-PMID31133756

H. sapiens

Title: Mitochondrial metabolism promotes adaptation to proteotoxic stress.

Screen Details:

Screen Rationale : Increased drug resistance
Cell Type : Chronic Myeloid Leukemia Cell Line [BTO:0002580]
Cell Line : K-562 [BTO:0000664, CELLOSAURUS:CVCL_0004]
Phenotype : Response To Chemicals
Condition : OTA-5781 (100.0 nM) [ChemSpider]
Library : Human Activity-optimized genome-wide library [AddGene] | Type: CRISPRn | Format: Pool | Enzyme: Cas9 | Methodology: Knockout
Analysis Method : Log2 Fold Change (L2FC) | Number of Hits: 1 | Full Dataset Size: 18,318
Experimental Setup : Drug Exposure | Duration: 34 Days
Significance : Authors have indicated that results with Score.1 (CRISPR Score (CS)) > 4.0 are to be considered significant. These results are indicated by 'Yes' in the HIT column of the table below.