CRISPR Screen Dataset
Li F (2019) - 1-PMID31744829
Title: In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma.
Screen Details:
- Screen Rationale : Cancer cell response to immune response
- Cell Type : Lung Cancer Cell Line [BTO:0000762, EFO:0002934]
- Cell Line : KP-Cas9-Clone 7 [CELLOSAURUS:CVCL_C9B0]
- Phenotype : Tumorigenicity
- Library : Targeted epigenetic regulator library (Wong, 2019) | Type: CRISPRn | Format: in vivo | Enzyme: Cas9 | Methodology: Knockout
- Analysis Method : MaGeCK | Number of Hits: 75 | Full Dataset Size: 727
- Experimental Setup : Implantation to Mouse Model | Duration: 24 Days | MOI: = 0.2
- Significance : Authors have indicated that results with Score.2 (p-Value) < 0.05 OR Score.4 (p-Value) < 0.05 are to be considered significant. These results are indicated by '' in the HIT column of the table below.
Score Distribution
< 1
> 0.00011982