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The Biological General Repository for Interaction Datasets (BioGRID) is an interaction, post-translational modification, and chemical association repository with data compiled through comprehensive curation efforts

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. Themed curation projects are updated monthly and additional projects are generated on a regular basis.

CRISPR Screen data in BioGRID ORCS can be accessed via the BioGRID ORCS REST web service. Screens in various formats can be fetched from the BioGRID ORCS REST Service over HTTPS, programmatically or in a browser.


Latest News

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

Project Proteins Publications Interactions Chemical
Interactions
PTMs
COVID-19 Coronavirus 110 330 22,324 - 156
Ubiquitin-Proteasome System 1,586 20,039 280,264 1,540 61,432
Fanconi Anemia 69 3,146 18,425 94 4,452
Glioblastoma 198 6,187 31,796 852 8,418
Autophagy 197 3,715 28,305 303 7,355
Saccharomyces cerevisiae Kinome 260 5,117 99,678 - 3,853

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

Posted: May 10th, 2021 - 02:49 PM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 76,687 publications. These additions bring our total number of non-redundant interactions to 1,611,895, raw interactions to 2,045,743, non-redundant chemical associations to 12,815, raw chemical associations to 29,093, Non-Redundant PTM Sites to 553,360 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: May 1st, 2021 - 02:15 AM

Our latest BioGRID ORCS CRISPR Database update adds a new screen from the study, "A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis" by Hundley FV et al. (Molecular Cell, 2021). In this study, chemical-genetic CRISPR screens were carried out to identify human Ubiquitin-Proteasome System (UPS) genes, including 629 E3 ligases and 56 DUBs, whose knockout led to increased or decreased resistance to specific compounds. These compounds targeted various biological processes, including proteostasis, cell signaling and metabolism, thereby indicating potential roles of the UPS hit genes in diverse cellular processes.

A special thanks to the authors Hundley FV, Sanvisens Delgado N, Marin HC, Carr KL, Tian R, and Toczyski DP and the Department of Biochemistry and Biophysics at the University of California San Francisco.

If you have a CRISPR Screen Dataset you'd like to deposit directly into the BioGRID ORCS CRISPR Database, please contact us at biogridadmin@gmail.com.

Posted: April 15th, 2021 - 01:19 AM

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

Project Proteins Publications Interactions Chemical
Interactions
PTMs
COVID-19 Coronavirus 110 314 22,244 - 50
Ubiquitin-Proteasome System 1,582 19,967 279,051 1,540 59,615
Fanconi Anemia 69 3,136 18,400 94 4,345
Glioblastoma 198 6,160 31,743 852 8,051
Autophagy 197 3,695 27,919 303 7,108
Saccharomyces cerevisiae Kinome 260 5,113 99,662 - 3,853

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

Posted: April 4th, 2021 - 02:49 PM

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 314 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 22,244 and 50 post-translational modifications including 20,296 interactions and 50 post-translational modifications from 213 publications and preliminary reports for SARS-CoV-2 (COVID-19) and 27 coronavirus-related CRISPR screens.

To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Posted: April 4th, 2021 - 07:44 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 76,506 publications. These additions bring our total number of non-redundant interactions to 1,589,475, raw interactions to 2,022,190, non-redundant chemical associations to 12,815, raw chemical associations to 29,093, Non-Redundant PTM Sites to 541,130 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: April 1st, 2021 - 03:57 AM

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 190 different publications. These additions bring the total number of curated CRISPR screens in our database to 1,364 encompassing 85,000+ genes, 716 different cell lines, 119 different cell types, and 19 different phenotypes across 4 different organisms (Human, Mouse, African Green Monkey, and Fruit Fly). Additionally, we've curated 27 coronavirus-related screens including 13 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

Posted: March 29th, 2021 - 01:16 AM

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 290 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 22,223 and 50 post-translational modifications including 20,301 interactions and 50 post-translational modifications from 194 publications and preliminary reports for SARS-CoV-2 (COVID-19) and 27 coronavirus-related CRISPR screens.

To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Posted: March 5th, 2021 - 07:44 AM

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

Project Proteins Publications Interactions Chemical
Interactions
PTMs
COVID-19 Coronavirus 110 290 22,223 - 50
Ubiquitin-Proteasome System 1,582 19,875 278,500 1,540 59,615
Fanconi Anemia 69 3,123 18,354 94 4,345
Glioblastoma 198 6,133 31,661 852 8,051
Autophagy 197 3,683 27,872 303 7,108
Saccharomyces cerevisiae Kinome 260 5,086 99,580 - 3,853

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

Posted: March 3rd, 2021 - 06:49 AM

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