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The Biological General Repository for Interaction Datasets (BioGRID) is an interaction, post-translational modification, and chemical association repository with data compiled through comprehensive curation efforts

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. Themed curation projects are updated monthly and additional projects are generated on a regular basis.

CRISPR Screen data in BioGRID ORCS can be accessed via the BioGRID ORCS REST web service. Screens in various formats can be fetched from the BioGRID ORCS REST Service over HTTPS, programmatically or in a browser.


Latest News

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 80,097 publications. These additions bring our total number of non-redundant interactions to 1,926,299, raw interactions to 2,475,167, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: June 1st, 2022 - 07:22 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,845 publications. These additions bring our total number of non-redundant interactions to 1,920,021, raw interactions to 2,467,140, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: May 1st, 2022 - 05:02 AM

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 266 different publications. These additions bring the total number of curated CRISPR screens in our database to 1,592 encompassing 86,000+ genes, 745 different cell lines, 127 different cell types, and 23 different phenotypes across 4 different organisms (Human, Mouse, African Green Monkey, and Fruit Fly). Additionally, we've curated 53 coronavirus-related screens including 24 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

Posted: May 4th, 2022 - 03:47 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,570 publications. These additions bring our total number of non-redundant interactions to 1,890,467, raw interactions to 2,424,838, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: April 2nd, 2022 - 03:32 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,457 publications. These additions bring our total number of non-redundant interactions to 1,878,962, raw interactions to 2,412,071, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: March 1st, 2022 - 05:42 AM

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

Project Proteins Publications Interactions Chemical
Interactions
PTMs
COVID-19 Coronavirus 110 507 28,576 - 156
Ubiquitin-Proteasome System 1,586 21,628 336,522 1,875 62,580
Fanconi Anemia 69 3,407 21,154 100 4,530
Glioblastoma 198 6,521 39,025 882 8,771
Autophagy 197 4,069 39,755 334 7,461
Saccharomyces cerevisiae Kinome 260 5,244 100,897 - 3,861

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

Posted: February 1st, 2022 - 02:47 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,067 publications. These additions bring our total number of non-redundant interactions to 1,868,254, raw interactions to 2,398,355, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: February 1st, 2022 - 01:19 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 78,774 publications. These additions bring our total number of non-redundant interactions to 1,864,111, raw interactions to 2,392,652, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: January 1st, 2022 - 04:56 AM

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

Project Proteins Publications Interactions Chemical
Interactions
PTMs
COVID-19 Coronavirus 110 473 28,423 - 156
Ubiquitin-Proteasome System 1,586 21,362 322,515 1,875 62,580
Fanconi Anemia 69 3,317 20,209 100 4,530
Glioblastoma 198 6,462 37,266 882 8,771
Autophagy 197 4,002 36,416 334 7,461
Saccharomyces cerevisiae Kinome 260 5,222 100,765 - 3,861

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

Posted: December 10th, 2021 - 02:49 PM

Partners

National Institutes of Health
National Institutes of Health - Office of Research Infrastructure Programs
Canadian Institutes of Health Research
Lunenfeld-Tannenbaum Research Institute
Princeton University
Universite de Montreal

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