Our latest BioGRID ORCS CRISPR Database update adds a new screen from the study, "A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis" by Hundley FV et al. (Molecular Cell, 2021). In this study, chemical-genetic CRISPR screens were carried out to identify human Ubiquitin-Proteasome System (UPS) genes, including 629 E3 ligases and 56 DUBs, whose knockout led to increased or decreased resistance to specific compounds. These compounds targeted various biological processes, including proteostasis, cell signaling and metabolism, thereby indicating potential roles of the UPS hit genes in diverse cellular processes.

A special thanks to the authors Hundley FV, Sanvisens Delgado N, Marin HC, Carr KL, Tian R, and Toczyski DP and the Department of Biochemistry and Biophysics at the University of California San Francisco.

If you have a CRISPR Screen Dataset you'd like to deposit directly into the BioGRID ORCS CRISPR Database, please contact us at biogridadmin@gmail.com.

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 314 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 22,244 and 50 post-translational modifications including 20,296 interactions and 50 post-translational modifications from 213 publications and preliminary reports for SARS-CoV-2 (COVID-19) and 27 coronavirus-related CRISPR screens.

To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 76,506 publications. These additions bring our total number of non-redundant interactions to 1,589,475, raw interactions to 2,022,190, non-redundant chemical associations to 12,815, raw chemical associations to 29,093, Non-Redundant PTM Sites to 541,130 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 190 different publications. These additions bring the total number of curated CRISPR screens in our database to 1,364 encompassing 85,000+ genes, 716 different cell lines, 119 different cell types, and 19 different phenotypes across 4 different organisms (Human, Mouse, African Green Monkey, and Fruit Fly). Additionally, we've curated 27 coronavirus-related screens including 13 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 290 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 22,223 and 50 post-translational modifications including 20,301 interactions and 50 post-translational modifications from 194 publications and preliminary reports for SARS-CoV-2 (COVID-19) and 27 coronavirus-related CRISPR screens.

To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 76,264 publications. These additions bring our total number of non-redundant interactions to 1,584,238, raw interactions to 2,015,809, non-redundant chemical associations to 12,815, raw chemical associations to 29,093, Non-Redundant PTM Sites to 498,893, Non-Redundant PTM Sites to 541,130 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.