As of January 2021 (Build 4.2.193), BioGRID has surpassed the 2 million curated interaction milestone. This update brings our total number of protein and genetic interactions to 2,005,220 with an additional 29,093 curated chemical-protein interactions and 563,881 unique curated post-translational modification sites. These data have been extracted by curation of more than 230,000 primary research publications that span more than 80 model organisms and human cells. An up to date overview of curation projects and database development is provided in the open access publication "The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions" by Oughtred et al (Protein Science 30:187-200 doi: 10.1002/pro.3978, PubMed).

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 164 different publications. These additions bring our total number of curated CRISPR screens in our database to 1,244 encompassing 85,599+ genes, 704 different cell lines, 118 different cell types, and 19 different phenotypes across 4 different organisms (Human, Mouse, African Green Monkey, and Fruit Fly). Additionally, we've curated 27 coronavirus-related screens including 13 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

The latest update of BioGRID (build 4.1.192) contains 1,700+ new SARS-CoV and SARS-CoV-2 - Affinity Capture-MS interactions from our latest featured dataset "Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV" by Stukalov A et al. (bioRxiv, 10.1101/2020.06.17.156455). This study uses affinity capture-mass spectrometry on SARS-CoV-2 and SARS-CoV bait proteins in order to identify cellular proteins contributing to COVID-19 and SARS viral infections, respectively. More than 1,700 high confidence interactions were detected between the viral bait proteins and 1,000+ host proteins in human A549 lung carcinoma cells, thereby revealing molecular interactions that are exclusive or shared between both SARS coronaviruses, while also highlighting the functionality of individual human proteins in relation to their vulnerability to SARS-CoV-2.

A big thanks to all authors of the Stukalov A (2020) study: Stukalov A, Girault V, Grass V, Bergant V, Karayel O, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad SM, Piras A, Tanzer M, Hansen FM, Engleitner T, Reinecke M, Lavacca TM, Ehmann R, Walfel R, Jores J, Kaster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M and Pichlmair A.

If you have interaction data you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 221 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 21,405 and 47 post-translational modifications including 19,524 interactions and 47 post-translational modifications from 127 publications and preliminary reports for SARS-CoV-2 (COVID-19) and 14 coronavirus-related CRISPR screens.

Specifically, this update features several promising new pre-publications including:

• Tang X (2020) - A study showing Transferrin receptor (TfR) is an alternative receptor to ACE2 for SARS-CoV-2 and drugs targeting TfR that may prevent and/or treat COVID-19
• Ichimura T (2020) - A study showing KIM-1/TIM-1 as alternative receptors to ACE2 for SARS-CoV-2 and drugs targeting KIM-1 that may prevent and/or treat COVID-19.
• Gao C (2020) - A study showing the Spike Protein interacts with Multiple Innate Immune Receptors MR/CD206, DC-SIGN/CD209, L-SIGN/CD209L, and MGL/CLEC10A/CD301

To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 75,868 publications. These additions bring our total number of non-redundant interactions to 1,569,788, raw interactions to 1,997,840, non-redundant chemical associations to 12,815, raw chemical associations to 29,093, Non-Redundant PTM Sites to 498,893, Raw PTM Sites to 902,354 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID update 4.2.191 includes a comprehensive update to our Drosophila melanogaster (Fruit Fly) dataset in collaboration with FlyBase - The Database of Drosophila Genes and Genomes. This update incorporates more than 4,000 new interactions increasing the total number of D. melanogaster interactions deposited in BioGRID to 82,934 from 8,024 publications. These interactions and all associated meta data are available immediately online via all standard BioGRID searches and supported download formats. You can also find these and many additional Drosophila resources available at flybase.org.

A special thanks to the FlyBase Consortium for their tireless curation efforts and in particular Julie Agapite for directly helping to facilitate the BioGRID collaboration.

If you have an interaction dataset you'd like to deposit directly into the BioGRID, please contact us at biogridadmin@gmail.com.

BioGRID update 4.2.191 includes a comprehensive update to our Caenorhabditis elegans (Nematode) dataset in collaboration with WormBase - The Nematode Information Resource. This update incorporates more than 9,600 new interactions increasing the total number of C. elegans interactions deposited in BioGRID to 39,207 from 1,531 publications. These interactions and all associated meta data are available immediately online via all standard BioGRID searches and supported download formats. You can also find these and many additional nematode resources available at wormbase.org.

A special thanks to the WormBase Team for their tireless curation efforts and in particular Jae Cho and Chris Grove for directly helping to facilitate the BioGRID collaboration.

If you have an interaction dataset you'd like to deposit directly into the BioGRID, please contact us at biogridadmin@gmail.com.

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 145 different publications. These additions bring our total number of curated CRISPR screens in our database to 1,201 encompassing 64,173+ genes, 698 different cell lines, 114 different cell types, and 18 different phenotypes across 3 different organisms (Human, Mouse, and Fruit Fly). Additionally, we've curated 14 coronavirus-related screens including 6 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 75,760 publications. These additions bring our total number of non-redundant interactions to 1,565,084, raw interactions to 1,992,321, non-redundant chemical associations to 12,201, raw chemical associations to 29,093, Non-Redundant PTM Sites to 498,893, Raw PTM Sites to 902,354 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.