Related Resources

The Biological General Repository for Interaction Datasets (BioGRID) is an interaction, post-translational modification, and chemical association repository with data compiled through comprehensive curation efforts

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. Themed curation projects are updated monthly and additional projects are generated on a regular basis.

CRISPR Screen data in BioGRID ORCS can be accessed via the BioGRID ORCS REST web service. Screens in various formats can be fetched from the BioGRID ORCS REST Service over HTTPS, programmatically or in a browser.


Latest News

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 290 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 22,223 and 50 post-translational modifications including 20,301 interactions and 50 post-translational modifications from 194 publications and preliminary reports for SARS-CoV-2 (COVID-19) and 27 coronavirus-related CRISPR screens.

To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Posted: March 5th, 2021 - 07:44 AM

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

Project Proteins Publications Interactions Chemical
Interactions
PTMs
COVID-19 Coronavirus 110 290 22,223 - 50
Ubiquitin-Proteasome System 1,582 19,875 278,500 1,540 59,615
Fanconi Anemia 69 3,123 18,354 94 4,345
Glioblastoma 198 6,133 31,661 852 8,051
Autophagy 197 3,683 27,872 303 7,108
Saccharomyces cerevisiae Kinome 260 5,086 99,580 - 3,853

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

Posted: March 3rd, 2021 - 06:49 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 76,264 publications. These additions bring our total number of non-redundant interactions to 1,584,238, raw interactions to 2,015,809, non-redundant chemical associations to 12,815, raw chemical associations to 29,093, Non-Redundant PTM Sites to 498,893, Non-Redundant PTM Sites to 541,130 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: March 1st, 2021 - 02:16 AM

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

Project Proteins Publications Interactions Chemical
Interactions
PTMs
COVID-19 Coronavirus 110 260 22,087 - 50
Ubiquitin-Proteasome System 1,582 19,822 277,555 1,540 57,315
Fanconi Anemia 69 3,113 18,321 94 4,138
Glioblastoma 198 6,112 31,517 852 7,621
Autophagy 197 3,673 27,793 303 6,709
Saccharomyces cerevisiae Kinome 260 5,075 99,305 - 3,853

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

Posted: February 2nd, 2021 - 06:49 AM

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 260 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 22,087 and 50 post-translational modifications including 20,199 interactions and 50 post-translational modifications from 164 publications and preliminary reports for SARS-CoV-2 (COVID-19) and 27 coronavirus-related CRISPR screens.

To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Posted: February 1st, 2021 - 06:49 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 76,105 publications. These additions bring our total number of non-redundant interactions to 1,578,886, raw interactions to 2,008,912, non-redundant chemical associations to 12,815, raw chemical associations to 29,093, Non-Redundant PTM Sites to 498,893, Non-Redundant PTM Sites to 506,485 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: February 1st, 2021 - 03:14 AM

As of January 2021 (Build 4.2.193), BioGRID has surpassed the 2 million curated interaction milestone. This update brings our total number of protein and genetic interactions to 2,005,220 with an additional 29,093 curated chemical-protein interactions and 563,881 unique curated post-translational modification sites. These data have been extracted by curation of more than 230,000 primary research publications that span more than 80 model organisms and human cells. An up to date overview of curation projects and database development is provided in the open access publication "The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions" by Oughtred et al (Protein Science 30:187-200 doi: 10.1002/pro.3978, PubMed).

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: January 1st, 2021 - 07:53 AM

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 164 different publications. These additions bring our total number of curated CRISPR screens in our database to 1,244 encompassing 85,599+ genes, 704 different cell lines, 118 different cell types, and 19 different phenotypes across 4 different organisms (Human, Mouse, African Green Monkey, and Fruit Fly). Additionally, we've curated 27 coronavirus-related screens including 13 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

Posted: December 29th, 2020 - 01:16 AM

The latest update of BioGRID (build 4.1.192) contains 1,700+ new SARS-CoV and SARS-CoV-2 - Affinity Capture-MS interactions from our latest featured dataset "Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV" by Stukalov A et al. (bioRxiv, 10.1101/2020.06.17.156455). This study uses affinity capture-mass spectrometry on SARS-CoV-2 and SARS-CoV bait proteins in order to identify cellular proteins contributing to COVID-19 and SARS viral infections, respectively. More than 1,700 high confidence interactions were detected between the viral bait proteins and 1,000+ host proteins in human A549 lung carcinoma cells, thereby revealing molecular interactions that are exclusive or shared between both SARS coronaviruses, while also highlighting the functionality of individual human proteins in relation to their vulnerability to SARS-CoV-2.

A big thanks to all authors of the Stukalov A (2020) study: Stukalov A, Girault V, Grass V, Bergant V, Karayel O, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad SM, Piras A, Tanzer M, Hansen FM, Engleitner T, Reinecke M, Lavacca TM, Ehmann R, Walfel R, Jores J, Kaster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M and Pichlmair A.

If you have interaction data you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Posted: December 20th, 2020 - 02:19 AM

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