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The Biological General Repository for Interaction Datasets (BioGRID) is an interaction, post-translational modification, and chemical association repository with data compiled through comprehensive curation efforts

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. Themed curation projects are updated monthly and additional projects are generated on a regular basis.

CRISPR Screen data in BioGRID ORCS can be accessed via the BioGRID ORCS REST web service. Screens in various formats can be fetched from the BioGRID ORCS REST Service over HTTPS, programmatically or in a browser.


Latest News

BioGRID update 4.2.191 includes a comprehensive update to our Drosophila melanogaster (Fruit Fly) dataset in collaboration with FlyBase - The Database of Drosophila Genes and Genomes. This update incorporates more than 4,000 new interactions increasing the total number of D. melanogaster interactions deposited in BioGRID to 82,934 from 8,024 publications. These interactions and all associated meta data are available immediately online via all standard BioGRID searches and supported download formats. You can also find these and many additional Drosophila resources available at flybase.org.

A special thanks to the FlyBase Consortium for their tireless curation efforts and in particular Julie Agapite for directly helping to facilitate the BioGRID collaboration.

If you have an interaction dataset you'd like to deposit directly into the BioGRID, please contact us at biogridadmin@gmail.com.

Posted: November 16th, 2020 - 04:43 AM

BioGRID update 4.2.191 includes a comprehensive update to our Caenorhabditis elegans (Nematode) dataset in collaboration with WormBase - The Nematode Information Resource. This update incorporates more than 9,600 new interactions increasing the total number of C. elegans interactions deposited in BioGRID to 39,207 from 1,531 publications. These interactions and all associated meta data are available immediately online via all standard BioGRID searches and supported download formats. You can also find these and many additional nematode resources available at wormbase.org.

A special thanks to the WormBase Team for their tireless curation efforts and in particular Jae Cho and Chris Grove for directly helping to facilitate the BioGRID collaboration.

If you have an interaction dataset you'd like to deposit directly into the BioGRID, please contact us at biogridadmin@gmail.com.

Posted: November 6th, 2020 - 03:16 AM

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 145 different publications. These additions bring our total number of curated CRISPR screens in our database to 1,201 encompassing 64,173+ genes, 698 different cell lines, 114 different cell types, and 18 different phenotypes across 3 different organisms (Human, Mouse, and Fruit Fly). Additionally, we've curated 14 coronavirus-related screens including 6 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

Posted: November 1st, 2020 - 05:37 AM

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 75,760 publications. These additions bring our total number of non-redundant interactions to 1,565,084, raw interactions to 1,992,321, non-redundant chemical associations to 12,201, raw chemical associations to 29,093, Non-Redundant PTM Sites to 498,893, Raw PTM Sites to 902,354 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: November 1st, 2020 - 04:32 AM

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 215 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 21,395 and 47 post-translational modifications including 19,516 interactions and 47 post-translational modifications from 121 publications and preliminary reports for SARS-CoV-2 (COVID-19) and 14 coronavirus-related CRISPR screens.

To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Posted: October 29th, 2020 - 01:24 PM

Our latest BioGRID ORCS CRISPR Database update adds 3 new screens from the preprint study, "Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses" by Wang R et al. (BioRxiv, 2020.09.24.312298). In this preprint, the authors performed CRISPR screens in cells infected by SARS-CoV-2 as well as two seasonally circulating common cold coronaviruses, OC43 and 229E. These screens identified nearly 200 host proteins and their related pathways which may support coronavirus viral infection in a manner shared by mulitple members of the Coronaviridae family and over 390 genes whose loss reduced SARS-CoV-2 infection specifically. General host factors included SCAP activity and suggest cholesterol levels may play a role in coronavirus progression, which is consistent with recent interaction data published in the literature. The results of this study also suggest that the poorly characterized TMEM106B gene may play a role in SARS-CoV-2 progression exclusively.

A special thanks to the authors Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi JM, Carlson-Stevermer J, Oki J, Holden K, Krogan NJ, Ott M, and Puschnik AS and the Chan Zuckerberg Biohub, Synthego, Gladstone Institutes, and UCSF Quantitative Biosciences Institute.

If you have a CRISPR Screen Dataset you'd like to deposit directly into the BioGRID ORCS CRISPR Database, please contact us at biogridadmin@gmail.com.

Posted: October 20th, 2020 - 10:13 PM

The latest update of BioGRID (build 4.1.190) adds 11,000+ new SARS-CoV-2/Human Proximity Label-MS interactions from our latest two featured datasets "A SARS-CoV-2 BioID-based virus-host membrane protein interactome and virus peptide compendium: new proteomics resources for COVID-19 research" by St-Germain JR et al. (bioRxiv, 2020.08.28.269175) and "A SARS-CoV-2 - host proximity interactome" by Samavarchi-Tehrani P et al. (bioRxiv, 2020.09.03.282103). These two studies used proximity-dependent biotinylation labeling (BioID) coupled with mass spectrometric identification to uncover high confidence interactions between SARS-CoV-2 encoded proteins and human host cell proteins. These two virus-host interaction networks cover more than 1000 and 2000 host proteins, respectively. This work reveals new aspects of virus-host biology and suggests new candidate host targets for inhibition of viral replication. In addition to being available in BioGRID search results, downloads, and our REST service, the data from Samavarchi-Tehrani can also be accessed at covid19interactome.org.

A special thanks to Anne-Claude Gingras, Brian Raught and their colleagues for assistance with loading the data and a big thanks, of course, to all authors of the St-Germain (2020) study: St-Germain JR, Astori A, Samavarchi-Tehrani P, Abdouni H, Macwan V, Kim D, Knapp JJ, Roth FP, Gingras A, and Raught B and all authors of the Samavarchi-Tehrani P (2020) study: Samavarchi-Tehrani P, Abdouni H, Knight JD, Astori A, Samson R, Lin Z, Kim D, Knapp JJ, St-Germain J, Go CD, Larsen B, Wong CJ, Cassonnet P, Demeret C, Jacob Y, Roth FP, Raught B, and Gingras A as well.

If you have interaction data you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Posted: October 6th, 2020 - 04:11 PM

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 204 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 20,352 including 19,112 interactions from 110 publications and preliminary reports for SARS-CoV-2 (COVID-19) and 3 coronavirus-related CRISPR screens.

To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Posted: October 1st, 2020 - 06:24 AM

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 114 different publications. These additions bring our total number of curated CRISPR screens in our database to 1,042 encompassing 60,309+ genes, 671 different cell lines, 112 different cell types, and 17 different phenotypes across 3 different organisms (Human, Mouse, and Fruit Fly).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

Posted: October 1st, 2020 - 05:37 AM

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